Tombstone

Tombstone is a crime-boss working under the name Big Man. He serves as the secondary antagonist of the series, appearing in the first season as a minor antagonist of the Biology arc, the main antagonist of the Economics arc, one of the secondary antagonists of the Chemistry arc and a supporting antagonist of the Psychology arc and in the second season as the main antagonist of the Criminology arc.

Squashing the spider
Tombstone hired Alex O'Hirn and Flint Marko to rob the Jewellery Center. He witnessed how they were taken by Spider-Man on a live feed and told Hammerhead to get the Enforcers. When Hammerhead assembled the Enforcers in a warehouse, he told them about Spider-Man and ordered to kill him.

Background in other media

 * This is Tombstone's second animated appearance. He previously appeared in Spider-Man: The Animated Series where he gained superpowers in a laboratory accident.